Particle Kinematics in Spheronization of Pharmaceutical Pellets [Partikelkinematik in der Sphäronisation pharmazeutischer Pellets]
Weis, D. and Niesing, M. and Thommes, M. and Antonyuk, S.
Volume: 89 Pages: 1083-1091
For the production of pharmaceutical pellets, a combined extrusion and spheronization process is widely used, where the particle kinematics strongly influences the rounding in the spheronizer. In this study, the particle kinematics of the actual pharmaceutical pellets was analyzed. For this purpose, material parameters, such as coefficient of restitution and rigidity while loading and unloading, were determined by pressure and impact tests. Based on these parameters, a contact model for the simulation of the particle movement was developed. The simulation results were validated with experimental investigations. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim